Mouse complement components C4 and Slp act synergistically in a homologous hemolytic C4 assay
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چکیده
منابع مشابه
C3 and C4 Complement Levels in Iron Deficiency Anemia
Background and Objectives: Complement proteins are some of the most important plasma proteins of the innate immune system. Impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. This study was conducted to show whether serum C3 and C4 complement change in adult nonpregnant female with iron deficient anemia or ...
متن کاملTissue-specific variation in C4 and Slp gene regulation.
C4 and Slp are highly homologous mouse genes that differ in function and regulation. Allelic variants exist in quantitative regulation of C4 and in hormonal regulation of Slp. We have examined expression in several tissues, including liver and peritoneal macrophages which are the major sites of synthesis, using a probe that allows direct comparison of C4 and Slp mRNAs. Correctly-sized and initi...
متن کاملc3 and c4 complement levels in iron deficiency anemia
background and objectives: complement proteins are some of the most important plasma proteins of the innate immune system. impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. this study was conducted to show whether serum c3 and c4 complement change in adult nonpregnant female with iron deficient anemia or ...
متن کاملComplement C3 and C4 and Metabolic Syndrome
The complement system is part of the innate immune system and plays a role in regulating inflammation. Increased inflammation is engaged in the development of adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis, and hypertension. Adipose tissue not only produces complement but is also a potential target for complement activity. Obese adults and adults with c...
متن کاملMultiple C4/Slp genes distinguished by expression after transfection.
The S region of the murine major histocompatibility complex contains two closely related genes: C4, encoding the fourth component of complement, and Slp, encoding sex-limited protein. We cloned these genes from a cosmid library of the B10.W7R strain that does not show androgen regulation of the Slp protein. Restriction site polymorphisms revealed at least four C4-like genes within the Sw7 locus...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2000
ISSN: 0014-2980,1521-4141
DOI: 10.1002/(sici)1521-4141(200005)30:5<1507::aid-immu1507>3.0.co;2-c